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目的观察肾衰营养胶囊对慢性肾衰竭(CRF)营养不良大鼠的贫血状态的影响。方法以5/6肾切除的方法制作CRF模型,予4%酪蛋白饲料喂养制作CRF营养不良大鼠模型,将符合条件的随机分为模型组、中药组和开同组,同时设正常组。检测治疗前后大鼠体重、血清白蛋白、血红蛋白、红细胞计数、血清转铁蛋白受体、血清促红细胞生成素、血肌酐、血尿素氮。结果 CRF营养不良模型大鼠存在低白蛋白血症、贫血等营养不良问题,造模成功。与模型组比较,中药组摄食量和体重显著增加,血清白蛋白、血红蛋白、红细胞计数、血清转铁蛋白受体、血清促红细胞生成素水平明显升高,血肌酐、血尿素氮显著降低。结论肾衰营养胶囊可明显改善CRF营养不良模型大鼠的贫血,对CRF营养不良模型大鼠有肾保护作用。
Objective To observe the effect of Shenshuai Nutritional Capsule on anemia in rats with chronic renal failure (CRF) malnutrition. Methods CRF model was made by 5/6 nephrectomy and fed with 4% casein diet to make CRF malnutrition rat model. The rats were randomly divided into model group, Chinese herb group and Chinese herb group with normal group. Body weight, serum albumin, hemoglobin, red blood cell count, serum transferrin receptor, serum erythropoietin, serum creatinine and blood urea nitrogen were measured before and after treatment. Results The rats with CRF malnutrition had the problems of hypoalbuminemia, anemia and other malnutrition. Compared with the model group, the food intake and body weight of the Chinese herbal medicine group increased significantly, serum albumin, hemoglobin, erythrocyte count, serum transferrin receptor, serum erythropoietin levels were significantly increased, serum creatinine and blood urea nitrogen were significantly decreased. Conclusion Shenshuai Nutritional Capsule can significantly improve anemia in CRF malnutrition rats and protect rats with CRF malnutrition.