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目的：为了研究十二指肠球部溃疡（ＤＵ）与胃食管反流病（ＧＥＲＤ）的关系。方法：分别对６１例ＤＵ和２５例正常人（ＨＩ）进行２４ｈ食管ｐＨ值监测，ＤＵ组再分为有反流症状组１６例和无反流症状组４５例。结果：ＤＵ组１８例酸反流计分大于ＤｅＭｅｓｔｅｒ正常标准，占２９５％，显著高于ＨＩ组，差异有显著性意义（Ｐ＜００１），有反流症状组１６例全部酸反流计分大于ＤｅＭｅｓｔｅｒ正常标准，占１０００％，显著高于ＤＵ组、无反流症状组和ＨＩ组，差异有显著性意义（Ｐ＜００１）。结论：１６例有反流症状病人全部诊断ＧＥＲＤ、ＤＵ并ＧＥＲＤ占２６２％，两者关系密切。
Objective: To study the relationship between duodenal ulcer (DU) and gastroesophageal reflux disease (GERD). Methods: The serum levels of esophageal mucosa in 61 cases of DU and 25 cases of normal persons (HI) were monitored respectively. The DU group was divided into reflux group (16 cases) and non-reflux group (45 cases). Results: 18 cases of acid reflux score of DU group was greater than the normal standard of DeMester, accounting for 295%, significantly higher than HI group, the difference was significant (P <001), 16 patients with reflux symptom group all acid Reflux score was greater than the normal standard DeMester, accounting for 100%, significantly higher than the DU group, no symptoms of reflux group and HI group, the difference was statistically significant (P <0 01). Conclusion: 16 patients with reflux symptoms diagnosed GERD, DU and GERD accounted for 26 2%, both closely related.