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目的:比较10d序贯疗法与传统三联疗法根除幽门螺杆菌(Hp)的临床效果,并作药物经济学评价。方法:运用最小成本分析对10d序贯疗法(A组)与14d三联疗法(B组)治疗Hp阳性两种治疗方案进行分析评价。结果:两种方案的Hp根除率分别为92.50%,93.75%;临床有效率分别为96.25%,97.50%,两组差异无统计学意义(P>0.05);A组成本为798.10元,B组成本为920.98元。结论:10 d序贯疗法与传统三联疗法同样有效,而前者更经济。
Objective: To compare the clinical efficacy of 10 days sequential therapy and traditional triple therapy in the eradication of Helicobacter pylori (Hp), and to evaluate the pharmacological economics. Methods: The minimum cost analysis was used to analyze and evaluate the two treatment regimens of 10-day sequential therapy (group A) and 14-day triple therapy (group B). Results: The Hp eradication rates of the two regimens were 92.50% and 93.75% respectively. The clinical effective rates were 96.25% and 97.50%, respectively. There was no significant difference between the two groups (P> 0.05). The cost of group A was 798.10 yuan, This is 920.98 yuan. Conclusions: 10-day sequential therapy is as effective as traditional triple therapy, while the former is more economical.