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目的：探讨文拉法辛缓释片联合体育疗法治疗难治性抑郁症的疗效及安全性。方法将74例难治性抑郁症患者随机分为两组，均口服文拉法辛缓释片治疗，研究组联合体育疗法，观察8周。治疗前后采用汉密顿抑郁量表、汉密顿焦虑量表评定临床疗效，副反应量表评定不良反应。结果治疗后两组汉密顿抑郁量表、汉密顿焦虑量表评分均较治疗前呈持续下降（P＜0.05或0.01），治疗8周末研究组显效率73.0％、总有效率83.8％，对照组分别为48.6％、62.2％，研究组显效率、总有效率显著高于对照组（ P＜0.05）。两组不良反应均较轻微，不良反应发生率比较差异无显著性（ P＞0.05）。结论文拉法辛缓释片联合体育疗法治疗难治性抑郁症具有增效作用，疗效显著，安全性高。“,”Objective To explore the efficacy and safety of venlafaxine sustained‐release tablets plus phys‐ical therapy in the treatment of treatment‐resistant depression (TRD) .Methods Seventy‐four TRD pa‐tients were randomly assigned to two groups ,both groups took orally venlafaxine sustained‐release tab‐lets ,research group was plus physical therapy for 8 weeks .Efficacies were assessed with the Hamilton De‐pression Scale (HAMD) and Hamilton Anxiety Scale(HAMA)before and after treatment and adverse reac‐tions with the Treatment Emergent Symptom Scale (TESS) .Results After treatment the HAMD and HAMA scores of both groups lowered continuously compared with pretreatment (P<0.05 or 0.01) ,at the end of the 8th week obvious and total effective rate were respectively 73.0% and 83.8% in research group and 48.6% and 62.2% in control group ,the former was significantly higher than the latter (P 0.05) .Conclusion Venlafaxine sustained‐release tablets plus physical therapy has synergism ,evident effect and higher safety in the treatment of treatment‐resistant depression .