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采用~3H-2-脱氧葡萄糖(~3H-2-DG)定量方法研究大鼠听源性发作后各脑区葡萄糖摄取率的变化。实验动物每天在强声(115±5dB)刺激下诱导发作一次,共五次发作;对照动物为未经强声刺激的易感性大鼠。第六天,实验动物和对照动物都在安静的状态下测定其各脑区的糖代谢率。结果表明反复听源性发作之后,几乎所有的脑区都出现糖代谢率增高(p<0.05),其中下丘、上撖榄核、外侧丘系核、上丘增高更明显(p<0.01)。提示这些脑区可能与大鼠听源性发作的起源及传播途径有关。
The changes of glucose uptake in various brain regions of rats after auditory seizure were studied by ~ 3H-2-deoxyglucose (~ 3H-2-DG) quantitative method. The experimental animals were induced to attack once daily with strong sound (115 ± 5 dB) for a total of five episodes; the control animals were predisposed rats without strong acoustic stimulation. On the sixth day, the experimental animals and control animals were measured in the quiet state of each brain area of glucose metabolism. The results showed that after repeated episodes of auditory seizures, almost all of the brain areas showed increased glucose metabolism rate (p <0.05), of which, the inferior colliculus, the superior medulla oblongata nucleus, the lateral colliculus, the superior colliculus increased more significantly (p <0.01) . Suggesting that these brain regions may be related to the origin of the onset of auditory seizures and the route of transmission.