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二氧化硅(矽尘)可能致人类肾毒性从前经常由印象性报告和无对照的矽肺病人的临床研究中提出。检查33名接触矽尘的男性工人(平均工作时间为16年)以及19名以往没有原发性或继发性肾病病史,年龄相当的非接触矽尘的男性受验者排尿中白蛋白,α-1—1微球蛋白(AMG)和β—N—乙酰——苷氨酶(NAG)。接触矽尘工人尿中白蛋白和AMG排出量显著升高。矽肺受验者(7名)的白蛋白,AMG和NAG排出量也显著增高。除一人外,全部矽肺人在本研究开始3到17年前已停止接触矽尘。我们的发现表明,接触矽尘工人中慢性不可逆的肾脏毒性与延长接触时间有关。
Silica (silica dust) may have caused human nephrotoxicity in the past often presented in clinical studies by impressionistic reporting and uncontrolled silicosis patients. A total of 33 male workers exposed to silica dust (average working time of 16 years) and 19 male subjects without age history of primary or secondary nephropathy without contact with silica dust were examined for urinary albumin, α -1-1 microglobulin (AMG) and β-N-acetylglucosaminidase (NAG). Exposure to silica dust urine albumin and AMG significantly increased emissions. Albumin, AMG, and NAG excretion from silicosis subjects (n = 7) was also significantly increased. Except for one person, all silicographers stopped touching silica dust three to 17 years before the start of the study. Our findings indicate that chronic irreversible nephrotoxicity in workers exposed to silica dust is associated with prolonged exposure time.