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二甲双胍是临床上广泛应用的治疗2型糖尿病的药物。近年来不断有证据表明二甲双胍具有心脏保护作用,可提高心肌供能,促进一氧化氮的合成,改善胰岛素抵抗、抗炎、抗纤维化,抑制心肌细胞凋亡。同时研究显示二甲双胍的药理作用是通过激活腺苷激活的蛋白激酶实现。腺苷激活的蛋白激酶是一种重要的激酶,在调节糖脂代谢方面发挥着重要作用。
Metformin is clinically widely used in the treatment of type 2 diabetes drugs. In recent years there is continuous evidence that metformin has a cardioprotective effect, can improve myocardial energy supply, promote the synthesis of nitric oxide, improve insulin resistance, anti-inflammatory, anti-fibrosis and inhibit cardiomyocyte apoptosis. At the same time, studies show that the pharmacological effects of metformin are achieved by activating adenosine-activated protein kinase. Adenosine-activated protein kinase is an important kinase that plays an important role in the regulation of glycolipid metabolism.