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“胀痛消”由左金丸加味组成，临床用于胃肠道疾病取得了较好疗效。本文以胃排空、小肠推进及离体肠管解痉试验观察胀痛消胶囊的胃肠道药理作用。动物雌雄兼用，随机分组，分别观察该药对正常及胃复安、阿托品负荷小鼠胃排空的影响和对正常及新斯的明、肾上腺素负荷小鼠小肠推进的影响，同时观察该药对家兔离体十二指肠自发活动的作用及拮抗氯化乙酰胆碱、氯化钡、组织胺所致离体回肠痉挛的作用。研究结果表明该药明显抑制正常小鼠的胃排空及胃复安所致胃排空加快，对阿托品所致胃排空减慢有协同作用；明显抑制正常小鼠小肠推进，对新斯的明所致小鼠小肠推进加快有明显抑制作用，但对肾上腺素所致小鼠小肠推进减慢没有明显影响；抑制家兔离体十二指肠自发活动以及拮抗氯化乙酰胆碱、氯化钡、组织胺所致家兔回肠痉挛性收缩。以上研究结果提示胀痛消具有调整胃肠运动亢进及缓解胃肠平滑肌痉挛的药理作用。
“Expansion and pain elimination” is composed of Zuojin Pills, which has been used clinically to achieve good curative effect on gastrointestinal diseases. In this study, gastric emptying, small intestine advancing and intestine spasm test in vitro were used to observe the gastrointestinal pharmacological effects of Zhangtongxiao capsule. Animals were used as male and female animals and randomly divided into groups. The effects of the drug on gastric emptying in normal and metoclopramide- and atropine-loaded mice, and the effects on the small intestine advancing in normal and neostigmine- and epinephrine-loaded mice were observed. The drug was also observed. The role of isolated rabbit duodenum on the spontaneous activity and antagonism of acetylcholine chloride, strontium chloride, histamine-induced isolated ileal spasm. The results showed that the drug significantly inhibited gastric emptying in normal mice and gastric emptying caused by metoclopramide, and had a synergistic effect on slowing gastric emptying caused by atropine; Ming-induced acute inhibition of small intestine in mice has a significant inhibitory effect, but there is no obvious effect on adrenal-induced slowing of small bowel propulsion; inhibition of spontaneous activity of isolated duodenum in rabbits and antagonism of acetylcholine chloride, strontium chloride, Histamine causes rabbit ileal contractions. The results of the above studies suggest that Patongxiao has the pharmacological effects of regulating gastrointestinal hyperkinesia and relieving gastrointestinal smooth muscle spasm.