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[目的]探讨C-erbB-2和FHIT在宫颈癌组织中的表达情况及临床意义。[方法]用免疫组化SP法检测72例宫颈癌、24例宫颈上皮内瘤变(CIN)、12例慢性宫颈炎组织中FHIT蛋白、C-erbB-2蛋白的表达。[结果]FHIT蛋白在宫颈癌组织中的阳性率明显低于CIN组织和慢性宫颈炎组织,分别为50.0%(36/72)、79.2%(19/24)和100.0%(12/12),三者间比较差异有统计学意义(P<0.05)。C-erbB-2在慢性宫颈炎组织、CIN及宫颈癌组织中的阳性率分别为0(0/12)、33.3%(8/24)和75.0%(54/72),三者比较差异有统计学意义(P<0.05);在宫颈癌组织中,随组织学病理分级的增加,FHIT蛋白表达阳性率逐渐下降,C-erbB-2表达阳性率则逐渐上升,差异有统计学意义(P<0.05);FHIT蛋白、C-erbB-2蛋白在宫颈癌组织中的表达呈负相关关系(r=-0.33,P<0.05)。[结论]FHIT、C-erbB-2在宫颈癌的发生、发展过程中起着重要的作用,联合检测可为宫颈癌的早期诊断及治疗提供必要的理论依据。
[Objective] To investigate the expression and clinical significance of C-erbB-2 and FHIT in cervical cancer. [Method] The expressions of FHIT protein and C-erbB-2 protein in 72 cases of cervical cancer, 24 cases of cervical intraepithelial neoplasia (CIN) and 12 cases of chronic cervicitis were detected by immunohistochemical SP method. [Results] The positive rate of FHIT protein in cervical cancer was significantly lower than that in CIN and chronic cervicitis (50.0% (36/72), 79.2% (19/24) and 100.0% (12/12), respectively) The difference between the three was statistically significant (P <0.05). The positive rates of C-erbB-2 in chronic cervicitis, CIN and cervical cancer were 0 (0/12), 33.3% (8/24) and 75.0% (54/72), respectively (P <0.05). The positive rate of FHIT protein gradually decreased and the positive rate of C-erbB-2 increased gradually with the increase of histological grade in cervical cancer (P <0.05), the difference was statistically significant (P <0.05). The expression of FHIT protein and C-erbB-2 protein in cervical cancer tissues was negatively correlated (r = -0.33, P <0.05). [Conclusion] FHIT and C-erbB-2 play an important role in the occurrence and development of cervical cancer. Combined detection may provide the necessary theoretical basis for the early diagnosis and treatment of cervical cancer.