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关于乙肝病毒感染与先天畸形关系的研究多着眼于病毒本身及其抗原。作者在回顾性研究中发现抗－ＨＢｓ可能与先天畸形发生有关。本文前瞻性队列研究结果表明，抗－ＨＢｓ阳性母亲的新生儿畸形发生率（３．１６％）显著高于抗－ＨＢｓ阴性母亲（１．３５％），Ｐ＝０．０１４１，再次证实抗－ＨＢｓ可能有致畸作用。随乙肝疫苗广泛接种，育龄妇女抗－ＨＢｓ阳性率越来越高，因此进一步探讨抗－ＨＢｓ致畸作用十分重要。
On the relationship between hepatitis B virus infection and congenital malformations more focused on the virus itself and its antigen. In a retrospective study, we found that anti-HBs may be associated with congenital malformations. Our prospective cohort study showed that the incidence of neonatal deformity in anti-HBs positive mothers (3.16%) was significantly higher than that in anti-HBs negative mothers (1.35%), P = 0.0141, HBs may have teratogenic effects. With extensive inoculation of Hepatitis B vaccine, the anti-HBs positive rate in women of childbearing age is getting higher and higher, so it is very important to further study the teratogenic effect of anti-HBs.