论文部分内容阅读
急性冠状动脉综合征(acute coronary syndrome,ACS)是全球死亡的主要原因。免疫功能在ACS发展中起着至关重要的作用,表观遗传调控对这种疾病中的血液免疫细胞的调节作用尚没有研究报道过。该研究应用循环免疫细胞进行表观基因组分析,以确定ACS中异常分化的甲基化基因。方法:纳入102例ACS患者和101名对照组人群,利用人450K甲基化
Acute coronary syndrome (ACS) is the leading cause of death worldwide. Immune function plays a crucial role in the development of ACS. The regulation of epigenetic regulation on blood immune cells in this disease has not been reported yet. The study used circulating immune cells for epigenomic analysis to identify abnormally differentiated methylated genes in ACS. METHODS: A total of 102 patients with ACS and 101 control subjects were enrolled in this study. They were methylated at 450K