论文部分内容阅读
目的:探讨不同类型冠心病患者血清脑钠肽(BNP)的差异并探讨其临床意义。方法:连续入选住院急性心肌梗死(AMI)患者25例、不稳定型心绞痛(UAP)患者30例、稳定型心绞痛(SAP)患者20例及对照组25例,测定BNP浓度,同时测定患者左心室射血分数(LVEF)、磷酸肌酸激酶(CK)、磷酸肌酸激酶同工酶(CK-MB)及肌钙蛋白T(TNT),并进行比较及相关分析。结果:AMI组BNP、CK、CK-MB、TNT结果与对照组比较差异有统计学意义(P<0.05);AMI组与UAP组BNP、CK、CK-MB、TNT结果比较差异有统计学意义(P<0.05);UAP组与SAP组及对照组BNP结果比较差异有统计学意义(P<0.05);AMI及UAP患者的BNP与CK、CK-MB、TNT之间有良好的正相关(P<0.05),与LVEF值呈负相关(P<0.05)。结论:不同类型冠心病患者血清BNP浓度存在差异,BNP可反映心肌坏死的程度并可作为预后监测及疗效观察的指标。
Objective: To investigate the difference of serum brain natriuretic peptide (BNP) in patients with different types of coronary heart disease and to explore its clinical significance. Methods: Totally 25 inpatients with acute myocardial infarction (AMI), 30 patients with unstable angina pectoris (UAP), 20 patients with stable angina pectoris (SAP) and 25 patients with control group were enrolled in this study. BNP concentration was measured and the left ventricular LVEF, CK, CK-MB and Troponin T (TNT) were measured and compared. Results: There were significant differences in BNP, CK, CK-MB and TNT between the AMI group and the control group (P <0.05). The differences of BNP, CK, CK-MB and TNT between the AMI group and the UAP group were statistically significant (P <0.05). There was significant difference in BNP between UAP group and SAP group and control group (P <0.05). There was a positive correlation between BNP and CK, CK-MB and TNT in patients with AMI and UAP P <0.05), but negatively correlated with LVEF (P <0.05). Conclusion: There are differences in serum BNP concentrations between different types of coronary heart disease. BNP can reflect the degree of myocardial necrosis and can be used as an indicator of prognosis monitoring and curative effect observation.