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1例38岁男性强直性脊柱炎患者因病情控制不佳,给予氨甲蝶呤(剂量不详)+沙利度胺150mg/d口服。4个月后症状好转,沙利度胺减量至100mg/d维持治疗,病情稳定。5个月后,患者出现不自主间歇排尿,伴尿频、尿急、夜尿次数增加。停用沙利度胺,单用氨甲蝶呤维持治疗,症状逐渐好转。再次加用沙利度胺,再次出现不自主间歇排尿,停用后症状消失。
One 38-year-old male with ankylosing spondylitis was given oral methotrexate (dose unknown) + thalidomide 150 mg / d due to poor control of disease. After 4 months the symptoms improved, thalidomide reduced to 100mg / d maintenance treatment, stable condition. Five months later, patients with involuntary intermittent urination, frequent urination, urgency, nocturnal urination increased. Thalidomide discontinued, methotrexate alone treatment, the symptoms gradually improved. Add thalidomide again, again involuntary intermittent urination, after stopping the symptoms disappear.