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目的观察补阳还五汤联合奥扎格雷钠治疗心源性脑栓塞的临床疗效。方法选取2014年2月—2015年11月于扶沟县人民医院住院治疗的心源性脑栓塞患者97例,随机分为对照组(n=48)与观察组(n=49)。对照组给予常规西药(包括低分子肝素钙、复方丹参注射液、甘露醇、右旋糖酐、抗血小板聚集等)治疗,观察组在对照组基础上加用补阳还五汤联合奥扎雷钠治疗。比较两组患者临床疗效、血液流变学指标、日常生活能力量表(BI)评分及美国国立卫生研究院卒中量表(NIHSS)评分情况。结果观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前两组患者全血高、低切黏度,血浆黏度、三酰甘油、胆固醇及纤维蛋白原水平比较,差异无统计学意义(P>0.05);治疗后观察组血液黏度、血浆黏度、三酰甘油、胆固醇及纤维蛋白原水平低于对照组,差异有统计学意义(P<0.05)。治疗前两组NIHSS评分及BI评分比较,差异无统计学意义(P>0.05);治疗后观察组NIHSS评分低于对照组,BI评分高于对照组,差异有统计学意义(P<0.05)。结论补阳还五汤联合奥扎格雷钠治疗心源性脑栓塞的疗效确切,可改善患者血液流变学指标及脑组织血液循环,并提高患者日常生活能力。
Objective To observe the clinical efficacy of Buyang Huanwu Decoction combined with ozagrel sodium in the treatment of cardiogenic cerebral embolism. Methods 97 patients with cardiogenic cerebral embolism hospitalized in Fugou County People’s Hospital from February 2014 to November 2015 were randomly divided into control group (n = 48) and observation group (n = 49). The control group was given routine Western medicine (including low molecular weight heparin, compound Salvia miltiorrhiza injection, mannitol, dextran, anti-platelet aggregation, etc.). The observation group was treated with Buyang Huanwu Decoction combined with Ozaretacide on the basis of the control group. The clinical efficacy, hemorheology, daily living ability (BI) scores and NIHSS score of the two groups were compared. Results The total effective rate in the observation group was higher than that in the control group, with significant difference (P <0.05). There was no significant difference between the two groups before and after treatment in whole blood high and low shear viscosity, plasma viscosity, triglyceride, cholesterol and fibrinogen levels (P> 0.05); after treatment, the blood viscosity, plasma viscosity, Acylglycerol, cholesterol and fibrinogen levels were lower than the control group, the difference was statistically significant (P <0.05). NIHSS score and BI score in the two groups before treatment had no significant difference (P> 0.05). After treatment, the NIHSS score in the observation group was lower than that in the control group, and the BI score was higher than that in the control group (P <0.05) . Conclusion Buyang Huanwu Decoction combined with ozagrel sodium in the treatment of cardioembolic cerebral infarction exact effect, can improve the patient’s blood rheology indicators and brain blood circulation, and improve patients’ daily living ability.