【摘 要】
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Using conventional imaging modalities,it is difficult to detect recurrent lesions in prostate cancer patients who have undergone biochemical relapse,especially in patients with low prostate-specific antigen (PSA) levels.We retrospectively reviewed the fil
【机 构】
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Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China;Department of Oncolo
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Using conventional imaging modalities,it is difficult to detect recurrent lesions in prostate cancer patients who have undergone biochemical relapse,especially in patients with low prostate-specific antigen (PSA) levels.We retrospectively reviewed the files of fifty patients with histopathologically confirmed prostate cancer who underwent 99mTc-labeled prostate-specific membrane antigen (PSMA) single-photon emission computed tomography (SPECT)/computed tomography (CT),magnetic resonance imaging (MRI),and bone scan within a 30-day period.PSMA-SPECT/CT indicated metastatic lesions in 39 patients and had a higher detection rate (78.0％) than bone scan (34.0％) or MRI (40.0％).The diagnostic efficiency of PSMA-SPECT/CT imaging for bone and lymph node metastases (50.0％ and 42.0％) was better than bone scan (34.0％ and 0.0％) or MRI (24.0％ and 20.0％).PSMA-SPECT/CT provided a higher detection rate at serum PSA levels of ≤1 ng ml-1,1-4 ng ml-1,4-10 ng ml-1,and ＞10 ng ml-1.No correlation was found between Gleason score,PSA level,and the tracer tumor/background ratio of metastatic lesions.With the aid of PSMA-SPECT/CT imaging,the therapeutic strategy was changed for 31 patients,and this may have enhanced their clinical outcome.In conclusion,PSMA-SPECT/CT imaging could detect more metastatic lesions and achieve a higher detection rate than conventional imaging modalities at different serum PSA levels in prostate cancer patients who had undergone biochemical relapse.
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