青霉素抗生作用的发现大大推动人们对微生物产生的代谢物的兴趣。大多数参予基本生命过程的代谢物已经清楚。但微生物还产生许多似乎不参予基本生命过程的物质,这些物质称为次级代谢物。次级代谢物的结构和生物合成途径显然涉及到生物合成酶的分离和特性方面的研究。为了对微生物次级代谢物生物合成进行人工控制,我们需要了解这些酶是如何进行调节的。生物活性物质若要进行工业化生产,首 The discovery of the antibiotic effect of penicillin greatly motivated people’s interest in metabolites produced by microorganisms. Most metabolites that participate in basic life processes are already clear. However, microbes also produce many substances that do not appear to participate in basic life processes, and these substances are called secondary metabolites. The structure and biosynthetic pathways of secondary metabolites apparently involve the study of the isolation and characterization of biosynthetic enzymes. In order to artificially control the biosynthesis of microbial secondary metabolites, we need to understand how these enzymes are regulated. Bioactive substances for industrial production, the first