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目的研究不同抗病毒治疗方案针对不同时期慢性乙型肝炎的临床治疗效果。方法选择2012年5月—2014年6月开封市传染病医院治疗慢性乙型肝炎的患者142例,将其分成清除组和耐受组,每组71例。两组患者均采用恩替卡韦法、干扰素-а法进行治疗,观察两组患者治疗效果。结果清除组治疗后HBV-DNA、AST、ALT、TBil等各项指标均明显低于对照组,差异有统计学意义(P<0.05)。结论免疫清除期是治疗慢性乙型肝炎的重要时间,采用恩替卡韦法、干扰素-а法进行治疗能有效的提高治疗效果,应该引起临床医生的重视。
Objective To study the clinical effect of different antiviral treatment programs on chronic hepatitis B at different stages. Methods From May 2012 to June 2014, 142 patients with chronic hepatitis B from Kaifeng Infectious Diseases Hospital were divided into clearance group and toleration group, with 71 cases in each group. Two groups of patients were treated with entecavir, interferon-a method of treatment, the two groups observed the effect of treatment. Results After treatment, the indexes of HBV-DNA, AST, ALT and TBil in the clearance group were significantly lower than those in the control group (P <0.05). Conclusion Immune clearance is an important time for the treatment of chronic hepatitis B. Entecavir therapy and interferon-a therapy can effectively improve the therapeutic effect, which should be taken seriously by clinicians.