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为探索基底神经节病变和失语症的关系,选择经头颅CT证实为首发单侧基底神经节病变患者40例,在发病2周、1个月及2个月分别进行失语症检查。同时,进行脑电地形图(BEAM)及CT图象标准化处理。结果显示,基底神经节性失语者病灶多在基底节区偏外侧、前部及上部。病变偏外侧者脑电地形图异常率高,且此类患者多有较重的听理解障碍,而尾状核受累者失语中有明显的构音障碍及音韵障碍。讨论了基底神经节性失语的临床特点,并认为导致失语的机制多与基底节病变直接或间接影响皮层语言区(血流量减少、代谢低下)有关,但尾状核似可作为言语的皮层下整合中枢,在部分患者的失语中起作用。
To explore the relationship between basal ganglia lesions and aphasia, 40 patients with primary unilateral basal ganglia lesions confirmed by cranial CT were selected. Aphasia was examined at 2 weeks, 1 month and 2 months after onset. At the same time, EEG topography (BEAM) and CT image standardization. The results showed that basal ganglia aphasia lesions mostly in the basal ganglia lateral, anterior and upper. The abnormality of the EEG topography in the lateral part of the lesion is high, and such patients have more severe hearing disturbances, while the amblyopia in the caudate nucleus has obvious dysarthria and phonological disorders. Discusses the clinical features of basal ganglia aphasia and argues that the mechanisms that lead to aphasia are mostly related to the involvement of basal ganglia lesions, either directly or indirectly, in the cortical linguistic area (reduced blood flow, hypometabolism), but the caudate nucleus may serve as a cortical sublingual The integration center, in some patients aphasia play a role.