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目的探讨急性百草枯(PQ)中毒患者血清胱抑素C(Cys C)与肾损伤的关系。方法急性PQ中毒患者101例,分为存活组和死亡组,并设对照组50例。存活组和死亡组患者分别于中毒后第1天、第3天及第5天检测血清Cys C、血尿素氮(BUN)、血肌酐(Cr)水平。对照组于体格检查当日采血检测。对3组数据进行分析比较。结果中毒组第3、5天Cys C、BUN、Cr水平均高于对照组(P<0.01,P<0.05);死亡组Cys C、BUN、Cr水平明显升高,与存活组比较,差异均有统计学意义(P<0.01,P<0.05)。结论血清Cys C能反映急性百草枯中毒患者早期肾损伤,有助于反映其预后。
Objective To investigate the relationship between serum cystatin C (Cys C) and renal damage in patients with acute paraquat (PQ) poisoning. Methods Acute PQ poisoning in 101 patients, divided into survival group and death group, and the control group of 50 patients. The serum Cys C, blood urea nitrogen (BUN) and serum creatinine (Cr) levels in the survivors and death patients were measured on the 1st, 3rd and 5th day after poisoning respectively. Control group on the day of physical examination blood test. Three groups of data for analysis and comparison. Results The levels of Cys C, BUN and Cr in poisoning group were significantly higher than those in control group (P <0.01, P <0.05). The levels of Cys C, BUN and Cr in death group were significantly higher than those in control group There was statistical significance (P <0.01, P <0.05). Conclusions Serum Cys C can reflect the early renal injury in patients with acute paraquat poisoning and help to reflect its prognosis.