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目的:探讨CD44s和CD44v8蛋白在膀胱尿路上皮细胞癌中的表达及其与临床病理的相关性。方法:应用免疫组织化学技术检测60例膀胱尿路上皮细胞癌和10例正常膀胱黏膜CD44s和CD44v8蛋白的表达。结果:CD44s在正常膀胱黏膜及膀胱尿路上皮细胞癌中都有不同程度的表达,60例膀胱尿路上皮细胞癌中阳性表达是25例(41.7%),阳性表达与肿瘤的病理分级,TNM分期相关,而与肿瘤的复发,数量无相关性,且分型表达与病理分级相关。CD44v8在正常膀胱黏膜无表达,60例膀胱尿路上皮细胞癌中阳性表达是28例(46.7%),与肿瘤的病理分级,TNM分期相关,而与肿瘤的复发,数量无相关性。结论:BTCC组织中CD44s和CD44v8有相关性,可作为判断膀胱尿路上皮细胞癌分级,分期的一个参考指标,联合检测可以可提高判断的敏感性。
OBJECTIVE: To investigate the expression of CD44s and CD44v8 in bladder urothelial carcinoma and its correlation with clinical pathology. Methods: The expressions of CD44s and CD44v8 in 60 cases of bladder urothelial carcinoma and 10 cases of normal bladder mucosa were detected by immunohistochemistry. Results: The expression of CD44s in normal bladder mucosa and bladder urothelial carcinoma were all significantly different. The positive expression of CD44s in bladder urothelial carcinoma was 25 (41.7%). The positive expression of CD44s was related to the tumor grade, TNM Staging, but not with the recurrence of tumor, the number of no correlation, and the type of expression and pathological grade related. No positive expression of CD44v8 in normal bladder mucosa was found in 28 cases (46.7%) of 60 cases of bladder urothelial carcinoma, which was correlated with tumor grade and TNM stage, but not with tumor recurrence and number. Conclusion: There is a correlation between CD44s and CD44v8 in BTCC tissue, which can be used as a reference index to judge the grade and staging of bladder urothelial carcinoma. Combined detection can improve the sensitivity of judgment.