p53－independent upregulation of p21^WAF1 in NIH 3T3 cells malignantly transformed by mot－2

来源 :细胞研究：英文版 | 被引量 : 0次 | 上传用户：jeff1986928

【摘要】

：

ot-2 protein is shown to interact with p53 and inhibit its transcriptional activation function.Mot-2 overexpressing stable clones of NIH 3T3 cells were malignan

【作者】

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TakaS WadhR

【机构】

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NationalInstituteofBioscienceandHuman－Technology,ChugaiResearchInstituteforMolecularMedicine

【出处】

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细胞研究：英文版

【发表日期】

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2001年1期

【关键词】

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成纤维细胞癌变 mot-2 P53 P21^WAF1 p16INK42 细胞周期蛋白D1 Mouse fibroblasts malignant trans

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ot-2 protein is shown to interact with p53 and inhibit its transcriptional activation function.Mot-2 overexpressing stable clones of NIH 3T3 cells were malignantly transformed,however,they had a high level of expression of a p53 downstream gene,P21waf1.Th

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p53－independent upregulation of p21^WAF1 in NIH 3T3 cells malignantly transformed by mot－2

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