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目的探讨简单易行的白内障囊外摘除（ｅｘｔｒａｃａｐｓｕｌａｒｃａｔａｒａｃｔｅｘｔｒａｃｔｉｏｎ，ＥＣＣＥ）加后房型人工晶体植入术后远期（半年至２年）后囊混浊（ｐｏｓｔｅｒｉｏｒｃａｐｓｕｌａｒｏｐａｃｉｔｙ，ＰＣＯ）的防治措施。方法对２８例（３１眼），其中外伤性白内障１６例（１６眼），并发性白内障６例（８眼），老年性白内障６例（７眼），行后房型人工晶体植入，术后第７天开始用５－氟尿嘧啶（５－ｆｌｕｏｒｏｕｒａｃｉｌ，５－Ｆｕ）结膜下注射，全程用５－Ｆｕ（４５ｍｇ），半年后随诊，按后囊混浊分级标准对疗效进行评价。结果本组３１只眼中０级（后囊透明）者２９眼占９３．５５％，Ⅰ级和Ⅱ级（后囊混浊）各１眼占６．４５％，即后囊混浊的发生率为６．４５％，明显低于其它报道（４０～５０％），而且所发生的２例后囊混浊未引起明显的视力下降，故有效防治率达１００％。结论５－Ｆｕ联合皮质类固醇局部应用是一种简便易行，安全有效的防治白内障术后后囊混浊的方法。
Objective To investigate the prevention and treatment of posteriorcapsularopacity (PCO) in simple (short-term) (six months to two years) ECCE and posterior chamber intraocular lens implantation. Methods Twenty-eight eyes (31 eyes), including 16 traumatic cataracts (16 eyes), 6 cases of complicated cataract (8 eyes) and 6 cases of senile cataract (7 eyes), were treated with posterior chamber intraocular lens implantation On day 7, subconjunctival injection of 5-fluorouracil (5-Fu) was started. The whole course was treated with 5-Fu (45 mg) for six months. The curative effect was evaluated according to the posterior capsular opacity grading standard. Results In this group, 29 eyes of grade 0 (posterior capsular transparency) accounted for 93.55% in 31 eyes, 6.45% in each of grade Ⅰ and Ⅱ (posterior capsular opacities), that is, the incidence of posterior capsule opacity was 6 .45%, significantly lower than other reports (40 ~ 50%), and the occurrence of 2 cases of posterior capsule opacity did not cause significant visual loss, so the effective control rate of 100%. Conclusion The topical application of 5-Fu in combination with corticosteroids is a simple, safe and effective method to prevent posterior capsular opacification after cataract surgery.