［目的］钠离子通道拮抗剂苯妥英钠对实验性局灶性脑梗死的影响．［方法］随机分为 ２组，用 线栓法制作大白鼠脑梗死模型，观测梗死２ｈ、再灌流４ｈ后，对照组和实验组脑梗死体积的变化．［结 果］苯妥英钠使脑梗死体积明显减小，与对照组相比有显著性差异．［结论］苯妥英销对实验性脑缺血性 损伤有脑细胞的保护作用． ［ [Objective] The effect of sodium channel antagonist phenytoin on experimental focal cerebral infarction. [Methods] The rats were randomly divided into 2 groups. The model of cerebral infarction was established by thread occlusion. The changes of cerebral infarction volume in control group and experimental group were observed after 2 h of infarction and 4 h of reperfusion. [Results] Phenytoin reduced the volume of cerebral infarction significantly, which was significantly different from the control group. [Conclusion] Phenytoin can protect brain cells in experimental cerebral ischemic injury. [