目的观察CT引导下射频消融联合同步放化疗治疗晚期非小细胞肺癌的疗效。方法将75例非小细胞肺癌患者随机分为观察组和对照组,对照组患者采用常规EP方案,放疗为适形放疗。观察组行CT引导下射频消融联合同步放化疗治疗。结束治疗后比较2组治疗效果、第3个月KPS评分、3年内生存率和复发转移率、不良反应。结果观察组患者有效率为86.84%高于对照组的64.87%(P<0.05)。治疗结束3个月后观察组患者的KPS显著提升,对照组患者KPS评分下降,观察组患者的KPS评分显著高于对照组(P<0.05或P<0.01)。2组12个月、24个月生存率差异无统计学意义(P>0.05),观察组36个月生存率高于对照组,随访复发及转移率低于对照组(P<0.05)。结论 CT引导下射频消融联合放化疗治疗非小细胞肺癌的临床效果显著,影像引导下的微创介入治疗可作为肿瘤患者个体化治疗方案。 Objective To observe the effect of CT-guided radiofrequency ablation combined with concurrent chemoradiotherapy in the treatment of advanced non-small cell lung cancer. Methods Seventy-five patients with non-small cell lung cancer were randomly divided into observation group and control group. The control group received routine EP regimen and radiotherapy was conformal radiotherapy. The observation group underwent CT-guided radiofrequency ablation combined with concurrent radiotherapy and chemotherapy. After the end of treatment, the treatment effect of the two groups was compared. The KPS score of the third month, the survival rate within 3 years, the recurrence and metastasis rate, and adverse reactions were compared. Results The effective rate of the observation group was 86.84% higher than that of the control group (64.87%, P <0.05). The KPS of the observation group increased significantly after 3 months and the KPS score of the control group decreased. The KPS score of the observation group was significantly higher than that of the control group (P <0.05 or P <0.01). There was no significant difference in survival rate between the two groups at 12 months and 24 months (P> 0.05). The 36-month survival rate of the observation group was higher than that of the control group, and the recurrence and metastasis rate was lower than that of the control group (P <0.05). Conclusion CT-guided radiofrequency catheter ablation combined with chemoradiotherapy in the treatment of non-small cell lung cancer has a significant clinical effect. Image-guided minimally invasive intervention can be used as a personalized treatment for cancer patients.