为了证实几种雌激素靶组织对雌二醇(E_2)存在着不同的敏感性和了解雌激素受体在这些现象中所起的调节作用,作者用切除卵巢的雌鼠种植含各种不同剂量 E_2的硅橡胶作为动物模型,以观察其神经内分泌现象和雌激素在这些动物模型上产生的反应。首先选择成熟鼠(Sprague-Dewley)180～120g,置于设有光线和温度控制的环境中,12小时有灯光,12小时无灯光,用规定的饲料喂养。鼠龄达6～8周时切除卵巢,把术后2～4周的动物分为两组:对照组及分别种植含有1、10、50、100、 In order to confirm the different sensitivities of several estrogen target tissues to estradiol (E 2) and to understand the regulatory role estrogen receptors play in these phenomena, the authors used ovariectomized female mice to implant various doses E_2 silicone rubber as an animal model to observe its neuroendocrine phenotype and estrogen response to these animal models. First select the mature mouse (Sprague-Dewley) 180 ~ 120g, placed in a light and temperature control environment, 12 hours of light, 12 hours without light, feeding with the required feed. The ovariectomies were excised at the age of 6 to 8 weeks and the animals at 2 to 4 weeks after operation were divided into two groups: the control group,