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氟西丁(Fluoxetine)作为5—HT再摄取抑制剂除有良好的抗抑郁作用外,在动物实验中已显示出有抗痫作用,作者为证实在人体是否亦然而进行了临床研究。 共观察17例,男9例,女8例,年龄18～56岁,平均37.8±19岁,皆为复杂部分发作继发全身性发作,病程12～38年,平均20.1±8.1年,病因计有脑病变12例,Down氏综合征1例,原因不明4例。既往治疗,5例用卡马西平800～1600mg/日,11例用苯巴比妥100～200mg/日加卡马西平400～1600mg/日,1例用苯巴比妥100mg/日加丙戊酸
Fluoxetine, as a 5-HT reuptake inhibitor, has been shown to have anti-epileptic effects in animal experiments in addition to its good antidepressant effect. The authors conducted a clinical study to confirm whether they are in humans. A total of 17 cases were observed, 9 males and 8 females, aged 18 to 56 years, an average of 37.8 ± 19 years of age, are complicated by partial seizures secondary to systemic attacks, duration 12 to 38 years, an average of 20.1 ± 8.1 years, the etiology of There are 12 cases of brain lesions, Down’s syndrome in 1 case, 4 cases of unknown cause. Previous treatment, 5 cases with carbamazepine 800 ~ 1600mg / day, 11 cases with phenobarbital 100 ~ 200mg / day plus carbamazepine 400 ~ 1600mg / day, 1 case with phenobarbital 100mg / day plus propylene acid