作者以雄性Sprague-Dawley种大鼠按年龄8、10、12、15、19.5和24.5周,俸重分别为200、300、350、400、450和500克,分为6组,以观察汞的毒性和排出与年龄之间的关系。各组动物按每100克体重给予1毫升含不同浓度的氯化甲基汞玉米油溶液灌胃一次,单笼喂饲,自由进食。十天后测得各组的LD_(50)分别为39.6±2.3、33.1±2.1、30.3±1.0、27.1±1.0、24.7±1.5和23.9±1.1毫克汞/公斤。可见氯化甲基汞的LD_(50)随年龄增长而下降。200、350、450克三组继续观察20天,发现给予一次剂量25毫克汞/公斤氯化甲基汞的大鼠,除有体重变化外,尚有氯化甲基汞中毒的临床体征。如:腹泻、乏力、竖毛、失去食欲和中枢神经系统紊乱征候突然发作 The male Sprague-Dawley rats were aged 8, 10, 12, 15, 19.5 and 24.5 weeks and their pension weights were 200, 300, 350, 400, 450 and 500 g, respectively. Toxicity and discharge and the relationship between age. Each group of animals per 100 grams of body weight given to 1 ml with different concentrations of methylmercury chloride corn oil gavage once, a single cage feeding, free to eat. The LD50 of each group measured after ten days were 39.6 ± 2.3, 33.1 ± 2.1, 30.3 ± 1.0, 27.1 ± 1.0, 24.7 ± 1.5 and 23.9 ± 1.1 mg Hg / kg, respectively. Visible methylmercury LD_ (50) with age decline. 200,350,450 grams of three groups were observed for 20 days and found that given a dose of 25 mg mercury / kg of methylmercury methylmercury, in addition to weight changes, there are clinical signs of methylmercury methyl chloride poisoning. Such as: diarrhea, fatigue, hair loss, loss of appetite and central nervous system disorders sudden attack