肿瘤细胞与正常细胞在酶系上存在差别,利用这些差别,chakravarty等设计并合成缬-亮-赖三肽与苯二胺氮芥等抗肿瘤原药结合的抗肿瘤短肽药物,它们的抗肿瘤选择性比苯二胺氮芥等抗肿瘤原药提高5～7倍。我们在前文中报道了5-氟尿嘧啶乙酰(丙酰)二肽和三肽的合成及抗动物肿瘤试验,初步结果表 Tumor cells and normal cells in the enzyme there are differences in the use of these differences, chakravarty such as the design and synthesis of valine - light - relying on the triazine and benzodiazepine and other anti-tumor drugs combined anti-tumor short peptide drugs, their resistance Tumor selectivity than phenylamine nitrogen mustard and other anti-tumor drugs increased by 5 to 7 times. We have previously reported the synthesis of 5-Fluorouracil acetyl (propionyl) dipeptide and tripeptide and animal anti-tumor test, the preliminary results table