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目的:观察高压氧(HBO)预适应对高原颅脑损伤(TB I)大鼠行为学、局部脑血流(rCBF)、局部脑组织氧分压(PbtiO2)和脑含水量的影响,探讨高压氧预适应对高原颅脑损伤的神经保护作用。方法:SD大鼠42只随机分为平原组、高原组和高压氧预适应组,各组按Feeney自由落体撞击法造成TB I模型,采用Longa评分法进行神经功能缺损评分,采用Moor DRT4激光多普勒血流监测仪(LDF)和LICOX CMP组织氧分压监测仪分别监测伤区rCBF和PbtiO2变化。结果:伤后24 h高原组较平原组神经功能缺损评分上升,rCBF和PbtiO2下降,脑组织含水量增加,高压氧预适应组较高原组神经功能缺损评分下降(P<0.05),rCBF和PbtiO2升高(P<0.05和P<0.05),脑组织含水量降低(P<0.01)。结论:高压氧预适应对高原颅脑损伤具有神经保护作用,可以使rCBF和PbtiO2升高,脑组织水肿程度减轻,神经功能改善。
OBJECTIVE: To observe the effects of hyperbaric oxygen (HBO) preconditioning on behavior, regional cerebral blood flow (rCBF), partial cerebral oxygenation (PbtiO2) and brain water content in rats with high altitude brain injury (TBI) Neuroprotective effects of oxygen preconditioning on brain injury in high altitude. Methods: Forty-two Sprague-Dawley rats were randomly divided into three groups: Plank group, plateau group and hyperbaric oxygen preconditioning group. TBI model was induced by Feeney free-fall impact method, and neurological deficit score was assessed by Longa score method. Moor DRT4 laser Pulmonary blood flow monitor (LDF) and LICOX CMP tissue oxygen partial pressure monitor were monitored rCBF and PbtiO2 changes. Results: After 24 h, the neurological deficit scores of plateau group increased, rCBF and PbtiO2 decreased, brain water content increased, hyperbaric oxygen preconditioning group decreased significantly compared with plateau group (P <0.05), rCBF and PbtiO2 (P <0.05 and P <0.05), and the brain water content decreased (P <0.01). CONCLUSION: Hyperbaric oxygen preconditioning has neuroprotective effects on brain injury in high altitude. It can increase rCBF and PbtiO2, relieve edema of brain tissue and improve neurological function.