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目的分析医源性的双硫仑样反应的原因和心血管系统表现以及救治方法 ,提高临床医生对该疾病的认识并和心血管疾病相鉴别。方法对26例患者的临床资料进行回顾性分析。结果头孢菌素、硝基咪唑类和含乙醇成份的氢化可的松注射液、霍香正气水联用诱发双硫仑样反应居多,多数以心血管系统表现为主。所有的患者经过处理后,症状均逐渐好转,无一例死亡。结论医源性的双硫仑样反应在临床上并不多见,其表现为心血管系统症状,在输液过程中往往会误诊为输液反应或冠心病。因此提高对该病的认识十分必要。
Objective To analyze the causes of idiopathic disulfiram-like reaction and the cardiovascular system performance and treatment methods, and to improve clinicians’ understanding of the disease and differentiate them from cardiovascular diseases. Methods The clinical data of 26 patients were retrospectively analyzed. Results Cephalosporins, nitroimidazoles and hydrocortisone injection containing ethanol components, Huoxiangzhengqi water-induced predominate disulfiram-like reaction, most of the performance of the main cardiovascular system. All patients were treated, the symptoms are gradually improved, without a single death. Conclusions The iatrogenic disulfiram-like reaction is uncommon in clinical practice. Its manifestations are cardiovascular system symptoms. It is often misdiagnosed as infusion reaction or coronary heart disease during infusion. Therefore, raising awareness of the disease is necessary.