表皮生长因子受体活化与胰腺癌细胞解离关系的实验研究

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目的明确表皮生长因子受体(EGFR)活化参与胰腺癌细胞解离调节的分子机制。方法通过免疫荧光法检测仓鼠高转移株(PC-1.0)和低转移株(PC-1)胰腺癌细胞中EGFR、活化(磷酸化)EGFR(p-EGFR)、活化(磷酸化)丝裂原活化蛋白激酶激酶2(p-MEK1/2)及活化(磷酸化)细胞外信号调节激酶1/2(p-ERK1/2)的表达变化及其与胰腺癌细胞解离状态变化的关系。结果胰腺癌细胞解离因子(DF)明显诱导低转移株胰腺癌细胞(PC-1)中EGFR、p-EGFR、p-MEK1/2和p-ERK1/2的表达,同
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