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目的 检测急性感染性多发性神经根炎患儿急性期、恢复期血清及脑脊液中抗神经节苷脂GM1 IgG、IgM抗体变化 ,探讨该病的发病机制。方法 采用酶联免疫吸附试验方法研究 31例GBS患儿急性期、恢复期血清及脑脊液中抗神经节苷脂GM1 IgG、IgM抗体变化 ,设立两组对照组 ,即非GBS神经系统疾病组和正常组。结果 GBS患儿血清抗神经节苷脂GM1 IgM抗体OD均值高于二组对照组 (P <0 .0 5) ,脑脊液中抗GM1 IgM抗体OD均值高 ,与疾病对照组比较 (P <0 .0 5) ,血清抗GM1 IgG抗体OD均值高于正常组(P <0 .0 5)。结论 部分GBS患儿抗GM1 IgG、IgM抗体明显升高 ,尤其是在GBS亚型急性运动轴索神经病 (Acutemotoraxonalneur pathyAMAN)中升高显著 ,GM1 IgM抗体阳性率 75 %。表明 :神经节苷脂的免疫损伤在GBS发病中起重要作用 ,尤其在AMAN发病中作用显著
Objective To detect the changes of anti-ganglioside GM1 IgG and IgM in serum and cerebrospinal fluid (CSF) in acute and convalescent children with acute infectious multiple nerve root inflammation and to explore the pathogenesis of this disease. Methods Anti-ganglioside GM1 IgG and IgM antibody in serum and cerebrospinal fluid (CSF) of 31 children with GBS were studied by enzyme-linked immunosorbent assay (ELISA). Two control groups were established, namely, non-GBS neurological disease group and normal group. Results The mean OD value of anti-ganglioside GM1 IgM antibody in GBS children was higher than that of the control group (P <0.05). The mean OD value of anti-GM1 IgM antibody in cerebrospinal fluid was higher than that of the control group (P <0.05). The mean OD of serum anti-GM1 IgG was higher than that of normal group (P <0.05). Conclusion Some anti-GM1 IgG and IgM antibodies were significantly elevated in children with GBS, especially in GBS subtypes of Acutemotoraxonal neur pathyAMAN. The positive rate of GM1 IgM antibody was 75%. The results showed that the immunosuppression of gangliosides plays an important role in the pathogenesis of GBS, especially in the pathogenesis of AMAN