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本文对22例非何杰金氏病淋巴瘤(NHL)的中国患者和25例澳大利亚患者进行免疫组织化学的比较研究。两组患者的淋巴瘤组织切片均按美国国立癌症研究所1983年的工作分类方案作了病理分型,并以免疫过氧化酶物法进行比较形态学的观察。中国组内的瀰漫型、混合细胞性(小裂核细胞和大细胞)和组织细胞性NHL,较澳大利亚组为多;瘤细胞的浆细胞样分化和瘤组织间质内的嗜酸性白细胞浸润亦然。细胞浆内免疫球蛋白的检出,中国组(尤以具有浆细胞样分化者)较澳大利亚组为低。瘤细胞浆内免疫球蛋白的重链,中国组以γ为主,澳大利亚组则属μ和α。轻链的分配在中国组内无明显差别,在澳大利亚组则以λ居多。作者并探讨了上述差异的意义。
In this paper, 22 Chinese patients with non-Hodgkin’s lymphoma (NHL) and 25 Australian patients were compared for immunohistochemistry. Lymphoma tissue sections from both groups were pathologically classified according to the National Cancer Institute’s 1983 classification scheme and compared with immunoperoxidase method for morphological observation. The diffuse, mixed-cell (small-cell and large-cell) and histiocytic NHL in the Chinese group were significantly more than those in the Australian group; plasmacytoid differentiation of tumor cells and eosinophilic infiltration in the tumor interstitium Of course In the cytoplasm immunoglobulin detection, the Chinese group (especially those with plasmacytoid differentiation) was lower than the Australian group. The heavy chain of immunoglobulin in the cytoplasm of tumor cells is mainly γ in Chinese group and μ and α in Australian group. Light chain distribution in the Chinese group no significant difference in the Australian group is mostly λ. The author also explores the significance of these differences.