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目的:应用超声射频信号血管内中膜分析(quality intima-media thickness,QIMT)技术测量肥胖儿童的颈动脉内中膜厚度(intima-media thickness,IMT),探讨肥胖儿童代谢异常状况与颈动脉IMT间的关系。方法:由1名高年资超声医师应用QIMT技术,测量32例肥胖儿童(肥胖组)和20名正常对照儿童(对照组)的双侧颈总动脉IMT。结果:肥胖组与对照组儿童的空腹血糖(FBG)、总胆固醇(TCH)及低密度脂蛋白(LDL)差异均无统计学意义(P>0.05);肥胖组儿童的三酰甘油(TG)高于对照组,差异有统计学意义(P<0.01),高密度脂蛋白(HDL)则明显低于对照组,差异有统计学意义(P<0.05);肥胖组儿童的颈总动脉IMT明显高于对照组,差异亦有统计学意义(P<0.01)。结论:肥胖儿童的颈动脉IMT已开始增加,并可合并高脂血症,提示动脉硬化(AS)是可在小儿时期得病、成人发病。超声检查颈动脉IMT简便、安全无创,可作为早期发现AS的一个良好的预报因子。
OBJECTIVE: To measure the intima-media thickness (IMT) of carotid artery in obese children by using the quality oftima-media thickness (QIMT) technique and to investigate the relationship between metabolic abnormalities and carotid IMT Relationship between. Methods: A high-grade sonographer used QIMT technique to measure bilateral common carotid artery IMT in 32 obese children (obese group) and 20 normal control children (control group). Results: There was no significant difference in fasting blood glucose (FBG), total cholesterol (TCH) and low density lipoprotein (LDL) between obese and control children (P> 0.05) (P <0.01), HDL was significantly lower than the control group, the difference was statistically significant (P <0.05); obese group of carotid artery IMT was significantly Higher than the control group, the difference was also statistically significant (P <0.01). CONCLUSIONS: The carotid IMT in obese children has begun to increase and may be associated with hyperlipidemia, suggesting that atherosclerosis (AS) is a disease that can occur in infancy and in adults. Ultrasonography carotid IMT is simple, safe and noninvasive and can be used as a good predictor of early detection of AS.