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背景:胃泌素瘤是一种罕见的神经内分泌肿瘤,并且研究表明和Zollinger-Ellison综合征(ZES)相关,手术切除是唯一可以治愈胃泌素瘤的治疗方式,本研究评估单中心手术切除治疗胃泌素瘤的效果。方法病人资料来自于从1992年1月到2011年12月单中心进行手术评估和治疗胃泌素瘤的前瞻性数据库,其中包含胰腺癌和壶腹周围癌。另外,收集病理组织学诊断胃泌素瘤明确的组织标本。只有术前有ZES症状的病人包含在内,患者的神经内分泌肿瘤免疫组化
BACKGROUND: Gastrinoma is a rare neuroendocrine tumor and studies have shown that surgery is the only treatment that can cure gastrinomas in association with Zollinger-Ellison syndrome (ZES). This study evaluated single center excision Treatment of gastrinoma effect. Methods Patient information was obtained from a single-center prospective data base for the surgical evaluation and treatment of gastrinomas from January 1992 to December 2011, including pancreatic cancer and periampullary cancer. In addition, collect histological specimens for histological diagnosis of gastrinomas with clear histology. Only patients with preoperative ZES symptoms were included and the patient’s neuroendocrine tumor immunohistochemistry