多发性骨髓瘤(multiple myeloma,MM)是一种具有高度细胞遗传学异质性的恶性克隆性浆细胞病。随着对MM生物学特性的不断深入了解以及实验室和影像学新技术的应用,2014年国际骨髓瘤工作组(International Myeloma Working Group,IMWG)对MM诊断标准进行了修订~([1])。尽管此标准已发布了2年余,但其在临床应用中明显不足。本文将对IMWG修订后的MM诊断标 Multiple myeloma (MM) is a malignant clonal plasma cell disease with a high degree of cytogenetic heterogeneity. With the in-depth understanding of the biological characteristics of MM and the application of new technologies in laboratory and imaging, the International Myeloma Working Group (IMWG) revised the MM diagnostic criteria in 2014 ~ ([1]) . Although this standard has been released more than 2 years, but its clinical application is obviously inadequate. This article will review the IMWG revised MM diagnostic standard