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目的探讨带蒂卵巢器官移位术与游离卵巢器官移位术对宫颈癌患者卵巢功能的影响。方法采用前瞻性随机对照方法选取27例年轻宫颈癌患者,根据卵巢移位手术方法分为A组15例,采用双侧卵巢采用带蒂卵巢器官移位术治疗;B组12例,一侧卵巢行卵巢移位术,另一侧卵巢行卵巢游离器官异位移植术;对比两组患者手术前后不同时期的促卵泡成熟激素(FSH)、促黄体生成素(LH)、雌二醇(E2)的水平变化。结果术前A、B两组患者的血清FSH、LH、E2水平差异不具有统计学意义(P>0.05);术后3个月、6个月,A组患者的血清FSH、LH水平均高于B组患者(P<0.05),E2水平均低于B组(P<0.05);术后3个月、6个月,A组患者的Kupperman评分均高于B组(P<0.05);术后3个月、6个月,A组患者的卵巢衰竭的发生率分别为26.67%、6.67%,均高于B组患者的8.33%、0.00%,但差异不具有统计学意义(P>0.05)。结论游离卵巢器官移位术对宫颈癌患者卵巢功能的影响更小,但实际操作中手术难度较大。
Objective To investigate the effect of pediatric ovarian organ transposition and free ovarian organ transposition on ovarian function in patients with cervical cancer. Methods 27 cases of young patients with cervical cancer were selected by prospective randomized controlled study. According to the method of ovarian transposition, 15 cases in group A were treated with transposition of ovary and pedicled ovary. B group, 12 cases of ovarian Ovariectomy and ovary free ovary heterotopic transplantation on the other side. The changes of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) The level of change. Results There was no significant difference in serum FSH, LH and E2 levels between the two groups before surgery (P> 0.05). Serum levels of FSH and LH in group A were significantly higher at 3 and 6 months after operation The levels of E2 in group B were significantly lower than those in group B (P <0.05). The Kupperman scores of group A were significantly higher than those in group B at 3 months and 6 months after operation (P <0.05). The incidence of ovarian failure in group A was 26.67% and 6.67% at 3 months and 6 months after operation, respectively, which were higher than those in group B (8.33% and 0.00%, respectively), but the difference was not statistically significant (P> 0.05). Conclusion Free ovarian organ transposition has less effect on the ovarian function of patients with cervical cancer, but the operation is more difficult in practice.