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[目的]评价术前平阳霉素静脉化学治疗对高分化口腔鳞状细胞癌中Ki-67和Caspase-3蛋白表达的影响.[方法]用免疫组织化学PV-6000通用型二步法检测30例单纯手术组及15例术前平阳霉素静脉化学治疗组口腔鳞状细胞癌中Ki-67和Caspase-3蛋白的表达.[结果]与未行化学治疗组比较,静脉化学治疗组Ki-67蛋白表达明显降低(P<0.05),Caspase-3蛋白表达明显提高(P<0.05).[结论]高分化口腔鳞状细胞癌术前平阳霉素静脉化学治疗可抑制癌细胞增殖,诱导细胞凋亡.
[Objective] To evaluate the effect of preoperative pingyangmycin chemotherapy on Ki-67 and Caspase-3 protein expression in well-differentiated oral squamous cell carcinoma. [Methods] The immunohistochemical PV-6000 universal two-step method was used to detect 30 Cases of simple surgery group and 15 cases of preoperative Pingyangmycin vein chemotherapy group of oral squamous cell carcinoma of Ki-67 and Caspase-3 protein expression. [Results] Compared with the non-chemical treatment group, intravenous chemotherapy group Ki- 67 protein expression was significantly lower (P <0.05), and Caspase-3 protein expression was significantly increased (P <0.05). [Conclusion] Preoperative pingyangmycin intravenous chemotherapy can inhibit the proliferation of cancer cells, Apoptosis.