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目的:观察奥沙利铂(oxaliplatin,L-OHP)联合氟尿嘧啶(fluorouracil,5-Fu)、亚叶酸钙(leucovorin,CF)治疗晚期胃癌的近期疗效及毒副反应。方法:入选者为病理证实的晚期胃腺癌患者。化疗方案:L-OHP100mg/m2静脉滴注2h,d1,CF200mg/m2静脉滴注2h,d1 ̄2,5-Fu400mg/m2,静脉滴注2h,d1,5-Fu600mg/m2持续静脉泵入22h,d1 ̄2,每3周重复,至少完成3个周期后判效,4个周期以上为有效病例。结果:全组54例均可评价疗效及不良反应,治疗总周期221个周期,平均4.1个周期。CR7例(13.0%),PR24例(44.4%),有效率(CR+PR)59.3%,SD17例(31.5%),PD6例(11.1%)。主要不良反应为轻度感觉神经毒性,恶心、呕吐及骨髓抑制。结论:L-OHP联合5-Fu、CF治疗晚期胃癌疗效较好,不良反应轻,可耐受,是晚期胃癌化疗的良好选择之一,同样适用于新辅助化疗。
Objective: To observe the short-term curative effect and toxicity of oxaliplatin (L-OHP) plus fluorouracil (5-Fu) and leucovorin (CF) Methods: The selected patients with pathologically confirmed advanced gastric adenocarcinoma. Chemotherapy: L-OHP100mg / m2 intravenous infusion 2h, d1, CF200mg / m2 intravenous infusion 2h, d1 ~ 2,5-Fu400mg / m2, intravenous infusion 2h, d1,5-Fu600mg / m2 continuous intravenous infusion of 22h , d1 ~ 2, repeated every 3 weeks, at least 3 cycles after the completion of the judgment, more than 4 cycles for the effective cases. Results: All the 54 cases could evaluate the curative effect and adverse reaction. The total treatment period was 221 cycles with an average of 4.1 cycles. CR7 cases (13.0%), PR24 cases (44.4%), effective rate (CR + PR) 59.3%, SD17 cases (31.5%) and PD6 cases (11.1%). The main adverse reactions were mild sensory neurotoxicity, nausea, vomiting and myelosuppression. CONCLUSION: L-OHP combined with 5-Fu and CF is effective in treating advanced gastric cancer with mild adverse reactions and tolerability. It is also a good choice for advanced gastric cancer chemotherapy and is also suitable for neoadjuvant chemotherapy.