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目的观察醋酸奥曲肽与垂体后叶素治疗肝硬化食管、胃静脉曲张破裂出血的临床疗效。方法将84例患者随机分为2组,其中奥曲肽治疗组42例,首先用奥曲肽0.1mg静脉推注,然后以25～50μg/h维持,垂体后叶素对照组42例,垂体后叶素以0.2～0.4u/min维持。两组入选患者基本资料相似,具有可比性。结果治疗组,止血成功36例,失败6例,总有效率86%。对照组,止血成功34例,失败8例,总有效率81%。两组总有效率比较,差异无统计学意义。结论奥曲肽与垂体后叶素治疗肝硬化食管、胃静脉曲张破裂出血前者稍优于后者,差异无统计学意义。后者副作用发生率明显高于前者,差异有统计学意义。但对于原有心血管疾病及老年患者,应首选奥曲肽类生长抑素。
Objective To observe the clinical effect of octreotide acetate and vasopressin in the treatment of hepatic cirrhosis with esophageal and gastric variceal bleeding. Methods Eighty-four patients were randomly divided into 2 groups. Among them, 42 patients were treated with octreotide, and the patients were initially given 0.1 mg octreotide intravenously and then maintained at 25-50 μg / h. Pituitrin control group (n = 42) 0.2 ~ 0.4u / min to maintain. The two groups of selected patients with similar basic information, comparable. Results The treatment group, hemostasis was successful in 36 cases, 6 cases failed, the total efficiency of 86%. Control group, hemostasis was successful in 34 cases, 8 cases of failure, the total efficiency of 81%. The total effective rate between the two groups, the difference was not statistically significant. Conclusion The former octreotide and pituitrin in the treatment of cirrhosis of the esophagus and gastric variceal bleeding former slightly better than the latter, the difference was not statistically significant. The latter incidence of side effects was significantly higher than the former, the difference was statistically significant. But for the original cardiovascular disease and elderly patients, the preferred octreotide somatostatin.