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目的:探讨血清胰岛素样生长因子相关指标及白细胞介素与妊娠高血压疾病的关系。方法:选择妊娠期高血压患者34例,轻度子痫前期患者27例,重度子痫前期患者18例,健康产妇50例作为研究对象,采集血清并测定胰岛素样生长因子(IGF)-Ⅰ、IGF-Ⅱ、胰岛素样生长因子结合蛋白(IGFBP)-1、白介素(IL)-6、IL-8、IL-18含量,收集胎盘并测定IGF-Ⅰ、IGF-Ⅱ、IGFBP-1、IL-6、IL-8、IL-18含量。结果:妊娠期高血压组、轻度子痫前期组、重度子痫前期组胎盘组织和血清中IGF-Ⅰ、IGF-Ⅱ含量均显著低于健康对照组(P<0.05),IGFBP-1、IL-6、IL-8、IL-18含量均显著高于对照组(P<0.05);血清IGF-Ⅰ、IGF-Ⅱ含量与IL-6、IL-8、IL-18含量呈负相关,血清IGFBP-1含量与IL-6、IL-8、IL-18含量呈正相关。结论:血清IGF-Ⅰ、IGF-Ⅱ含量降低以及IL-6、IL-8、IL-1、IGFBP-1含量升高与妊娠高血压疾病的发生有关,IGF-I、IGF-II含量降低以及IGFBP-1含量升高与白细胞介素含量的升高密切相关。
Objective: To investigate the relationship between serum insulin-like growth factor (IGF-I) and interleukin (IL) and pregnancy induced hypertension (BPH). Methods: Thirty-four patients with gestational hypertension, 27 patients with mild preeclampsia, 18 patients with severe preeclampsia and 50 healthy mothers were enrolled in this study. Serum was collected and serum levels of insulin-like growth factor-I, The levels of IGF-Ⅱ, IGFBP-1, IL-6, IL-8 and IL-18 were measured and the placentas were collected for determination of IGF- 6, IL-8, IL-18 content. Results: The levels of IGF-Ⅰ and IGF-Ⅱ in placenta tissue and serum of gestational hypertension group, mild preeclampsia group and severe preeclampsia group were significantly lower than those of healthy control group (P <0.05), IGFBP-1, The contents of IL-6, IL-8 and IL-18 in serum were significantly higher than those in the control group (P <0.05). The contents of IGF-Ⅰ and IGF- Serum IGFBP-1 levels and IL-6, IL-8, IL-18 content was positively correlated. CONCLUSION: The decrease of serum IGF-I and IGF-II levels and the increase of IL-6, IL-8, IL-1 and IGFBP-1 levels are associated with the occurrence of pregnancy- Elevated IGFBP-1 levels are closely associated with elevated interleukin levels.