论文部分内容阅读
目的:探讨肠易激综合征(IBS)患者血清白细胞介素10(IL-10)、白细胞介素12(IL-12)和皮质醇(CO)浓度变化及它们在IBS中的可能作用和临床意义。方法:随机抽取来源于门诊和住院IBS患者和健康志愿者血清,采用放射免疫法测量血清IL-10、IL-12和CO浓度。结果:腹泻型IBS病人血清IL-10和CO含量显著高于正常(P<0.05),便秘型IBS病人血清内IL-10和CO水平也高于正常对照(P<0.05)。腹泻型和便秘型IBS病人血清内IL-10和CO水平之间差别无统计学意义(P>0.05)。腹泻型IBS组血清IL-12含量比正常组低(P<0.05),便秘型IBS组血清内IL-12水平也低于正常对照组(P<0.05)。腹泻型和便秘型组之间血清内IL-12水平差别无统计学意义(P>0.05)。结论:炎症因子和应激可能参与IBS发病。
Objective: To investigate the changes of serum interleukin 10 (IL-10), interleukin 12 (IL-12) and cortisol (CO) in patients with irritable bowel syndrome (IBS) and their possible roles in IBS and clinical significance. Methods: Serum samples from outpatients and inpatients with IBS and healthy volunteers were randomly selected and serum IL-10, IL-12 and CO concentrations were measured by radioimmunoassay. Results: Serum levels of IL-10 and CO in patients with diarrhea-type IBS were significantly higher than those in normal controls (P <0.05). Serum levels of IL-10 and CO in patients with constipation-type IBS were also significantly higher than those in controls (P <0.05). There was no significant difference between the levels of IL-10 and CO in serum of patients with diarrhea and constipation IBS (P> 0.05). The level of IL-12 in IBS group was lower than that in normal group (P <0.05), while the level of IL-12 in IBS group was lower than that of normal control group (P <0.05). There was no significant difference in serum IL-12 levels between diarrhea and constipation (P> 0.05). Conclusion: Inflammatory factors and stress may be involved in the pathogenesis of IBS.