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为确定 Starling效应在心泵急性低氧反应中的地位,以及心包对此反应的影响,把17条雄狗,分别在心包切开(A 组)和缝合(B 组)条件下进行实验。在连续、依次吸入空气、氧分压为89、70和55mmHg 的常压氧-氮混合气各30min,并最后吸入氮气时,分别记录不同低氧状况下的左室前后径超声图、左室压力,dp/dt,右室压力或主动脉压力和第二导联心电图。结果表明,重度低氧时,左室舒张期末直径显著增大,A组由对照值3.88±0.15cm(M±SE)增大至4.22±0.18cm(P<0.01);B组由3.53±0.13cm增至3.67±0.12cm(P<0.01),并伴以每搏直径变化的明显增大(A 组由对照值的4.4±0.2mm增至4.9±0.2mm P<0.05;B 组由3.2±0.1mm 增至3.8±0.2mm P<0.01)。左室压力-直径环在重度低氧时显著右移,环体面积不缩小。说明重度低氧时,Starling 效应对心脏搏血功能的调节具有重要作用。在严重低氧导致左室收缩压进行性降低时,迅速切开心包可有利于心泵功能的改善,提示,心包对 Starling 效应的充分发挥有限制作用。
To determine the role of Starling in cardiac pump response to acute hypoxia and the effect of pericardium on this response, 17 male dogs were tested under pericardial (A) and suture (B) conditions. In continuous, followed by inhalation of air, oxygen partial pressure of 89,70 and 55mmHg atmospheric oxygen - nitrogen mixture for 30min, and the last inhalation of nitrogen were recorded under different hypoxic conditions left ventricular anterior and posterior sonography ultrasound, left ventricular Pressure, dp / dt, right ventricular pressure or aortic pressure, and second lead electrocardiogram. The results showed that at the time of severe hypoxia, the diameter of left ventricular end-diastole increased significantly from 3.88 ± 0.15cm (M ± SE) to 4.22 ± 0.18cm (P <0.01) in group A, and from 3.53 ± 0.13 cm increased to 3.67 ± 0.12cm (P <0.01), accompanied by a significant increase of stroke volume (group A increased from 4.4 ± 0.2mm to 4.9 ± 0.2mm P <0.05 in group A; group B increased from 3.2 ± 0.1 mm to 3.8 ± 0.2 mm P <0.01). Left ventricular pressure-diameter ring significantly shifted to severe right hypoxia, ring body area does not shrink. Description of severe hypoxia, Starling effect on the regulation of cardiac stroke function has an important role. When severe hypoxia leads to progressive reduction of left ventricular systolic pressure, rapid pericardial incision may be beneficial to the improvement of cardiac pump function, suggesting that the pericardium has a limited effect on the Starling effect.