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目的观察肺表面活性剂治疗晚期早产儿呼吸窘迫综合征(respiratory distress syndrome,RDS)的临床效果。方法晚期早产RDS患儿58例,依据家属是否同意应用肺表面活性剂治疗分为2组,对照组36例给予吸氧、气管插管机械通气等常规治疗,观察组22例在对照组治疗基础上给予肺表面活性剂气管内滴入,比较2组治疗前及治疗6、12、24h时血pH、pa(O2)、pa(CO2)及pa(O2)/吸入氧分数(fraction of inspiratory oxygen,FiO2),并记录机械通气时间、吸氧时间、住院时间及并发症发生情况。结果 2组治疗后6、12、24h时血pa(O2)、pa(CO2)及pa(O2)/FiO2均较治疗前好转(P<0.05);观察组治疗后6、12、24h时pa(O2)及pa(O2)/FiO2、机械通气时间、吸氧时间及住院时间与对照组比较差异有统计学意义(P<0.05)。结论晚期早产RDS患儿应用肺表面活性剂治疗可有效改善氧合情况,缩短机械通气及住院时间。
Objective To observe the clinical effect of pulmonary surfactant in the treatment of respiratory distress syndrome (RDS) in advanced preterm infants. Methods Fifty-eight children with preterm delivery of RDS were divided into two groups according to whether their family members agreed to use pulmonary surfactant. The control group received conventional therapy such as oxygen inhalation and mechanical ventilation through tracheal intubation. The observation group received 22 cases of basic treatment The lungs were treated with intratracheal intratracheal instillation. The blood pH, pa (O2), pa (CO2) and pa (O2) / fraction of inspiratory oxygen before treatment and at 6, 12, , FiO2), and recorded mechanical ventilation time, oxygen time, hospital stay and complications. Results The blood pa (O2), pa (CO2) and pa (O2) / FiO2 were improved in both groups at 6, 12 and 24 hours after treatment (P <0.05) (O2) and pa (O2) / FiO2, mechanical ventilation time, oxygen inhalation time and hospital stay compared with the control group, the difference was statistically significant (P <0.05). Conclusions The application of pulmonary surfactant in preterm RDS patients can effectively improve oxygenation and shorten the duration of mechanical ventilation and hospital stay.