参与癌细胞侵袭、转移的粘附分子有四大类 ,其中整合蛋白家族成员层粘连蛋白 (L aminin,LN)及其受体 (Laminin receptor,LN- R)被证实在细胞分化、恶变、肿瘤侵袭、转移中起重要作用 ,深入研究 L N及其受体的粘着及信号传导机理 ,为肿瘤的发生、浸润及转移提供理论依据 ,本文就二者与妇科肿瘤的发病机理进行了综述。 There are four major types of adhesion molecules involved in the invasion and metastasis of cancer cells. Among them, laminin (LN) and its receptor (Laminin receptor, LN-R), which are integral members of the integrin protein, have been shown to be involved in cell differentiation, malignant transformation, and tumorigenesis. Invasion and metastasis play an important role in the study of adhesion and signal transduction mechanisms of LN and its receptors, providing a theoretical basis for the occurrence, invasion and metastasis of tumors. This article reviews the pathogenesis of both gynecologic tumors.