伊伐布雷定是高度特异性的If离子通道阻滞剂,通过抑制If电流降低窦房结节律,减慢心率,而对心内传导系统、心肌收缩力以及血流动力学无明显影响。很多基础和临床研究表明,伊伐布雷定能改善心力衰竭患者临床症状、提高生活质量、降低病死率及心血管事件发生率。 Ivabradine is a highly specific If ion channel blocker that suppresses the sinus node rhythm and slows down the heart rate by inhibiting the If current, with no significant effect on the intracardiac conduction system, myocardial contractility and hemodynamics. Many basic and clinical studies have shown that ivabradine can improve the clinical symptoms of patients with heart failure, improve quality of life, reduce mortality and cardiovascular events.