新诊断男性2型糖尿病患者血清维生素D与血糖、年龄关系的研究

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目的观察新诊断男性T2DM患者血清25羟维生素D[25(OH)D]水平,以及与血糖、年龄的关系。方法选取新诊断男性T2DM患者(T2DM组)240例及健康对照组(NC)80名。T2DM组再根据年龄及HbA_1c分别分组,分析25(OH)D、FPG、FIns、FC-P、TG、TC、HDL-C及LDL-C水平。结果T2DM组25(OH)D低于NC组(P=0.032),维生素D缺乏者比例较NC组升高(P=0.029)。T2DM组中,维生素D缺乏者比例≥60岁亚组,高于<45岁亚组(P=0.041),HbA_1c≥10%亚组高于<7%亚组(P=0.038)。≥60岁亚组及45~60岁亚组25(OH)D、FIns低于<45岁亚组(P=0.021、0.033、0.027、0.031);>60岁亚组FC-P低于<45岁亚组(P=0.042);≥60岁亚组HbA_1c高于<45岁亚组及45~60岁亚组(P=0.031、0.039)。HbA_1c≥10%亚组及HbA_1c 7%~10%亚组FPG高于HbA_1c<7%亚组(P=0.021、0.037),HbA_1c≥10%亚组FPG高于HbA_1c 7%~10%亚组(P=0.028);HbA_1c≥10%亚组FC-P较HbA_1c<7%亚组和HbA_1c 7%~10%亚组降低(P=0.022、0.029);HbA_1c≥10%亚组及HbA_1c7%~10%亚组25(OH)D较HbA_1c<7%亚组降低(P=0.017、0.032)。25(OH)D与HDL-C、FIns呈正相关(r=0.637,P=0.032;r=0.352,P=0.048),与年龄、HbA_1c呈负相关(r=-0.270,P=0.001;r=-0.237,P=0.046)。多元逐步回归分析结果显示,年龄、HbA_1c是25(OH)D的独立影响因素(P=0.003、0.016)。结论 T2DM患者易合并维生素D缺乏,年龄增越大、血糖水平越高,血清维生素D水平越低。 Objective To observe the serum 25-hydroxyvitamin D [25 (OH) D] level in newly diagnosed male patients with T2DM and its relationship with blood glucose and age. Methods Two hundred and forty new-diagnosed male patients with T2DM (T2DM group) and 80 healthy controls (NC) were enrolled. The levels of 25 (OH) D, FPG, FIns, FC-P, TG, TC, HDL-C and LDL-C in T2DM group were further divided into groups according to age and HbA_1c. Results 25 (OH) D in T2DM group was lower than that in NC group (P = 0.032), and the proportion of vitamin D deficiency group was higher than that in NC group (P = 0.029). In T2DM group, the proportion of vitamin D deficiency group was higher than 60 years in subgroup, higher than 45 years subgroup (P = 0.041), HbA 1c ≥ 10% subgroup was higher than <7% subgroup (P = 0.038). The FI (subscript a) was lower than 45 years old (P = 0.021,0.033,0.027, 0.031) in ≥60 years old subgroup and in 45-60 years old subgroup, and was lower than <45 (P = 0.042). HbA_1c in the group of ≥60 years old was higher than that in the group of <45 years old and the group of 45-60 years old (P = 0.031,0.039). FPG in HbA_1c≥10% subgroup and HbA_1c7% ~ 10% subgroup were higher than those in HbA_1c <7% subgroup (P = 0.021,0.037), FPG in HbA_1c≥10% subgroup was higher than that in HbA_1c7% -10% subgroup P = 0.028); HbA_1c≥10% subgroup FC-P was lower than HbA_1c <7% subgroup and HbA_1c 7% -10% subgroup (P = 0.022,0.029); HbA_1c≥10% subgroup and HbA_1c7% -10 % 25 (OH) D was lower than that of HbA_1c <7% (P = 0.017,0.032). 25 (OH) D was positively correlated with HDL-C and FIns (r = 0.637, P = 0.032; r = 0.352, P = 0.048) and negatively correlated with age and HbA 1c (r = -0.270, -0.237, P = 0.046). Multiple stepwise regression analysis showed that age, HbA_1c, was an independent predictor of 25 (OH) D (P = 0.003,0.016). Conclusions Patients with T2DM are easily associated with vitamin D deficiency. With age increasing, the higher the blood glucose level, the lower the serum vitamin D level.
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