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目的：建立高效液相色谱法测定氢醌软膏含量。方法：以甲醇－水（８０∶２０）为流动相，检测波长：２９１ｎｍ，色谱柱为ＤＥＬＴＡＰＡＫＣ１８（３．９ｍｍ×３０ｃｍ，１０μｍ）。上述色谱条件下，辅料中其它成分峰对氢醌测定无干扰，分离度Ｒ＞２。结果：处方回收率为９９．９％，相对标准差为０．９％。结论：氢醌与尼泊金丙酯和羟甲氧苯酮有较佳分离度，测定结果令人满意
Objective: To establish a method for the determination of hydroquinone ointment by high performance liquid chromatography. Methods: The mobile phase was methanol - water (80:20). The detection wavelength was 291 nm. The column was DELTAPAKC18 (3.9 mm × 30 cm, 10 μm). Under the above chromatographic conditions, the other components in the excipients did not interfere with the determination of hydroquinone, and the resolution R> 2. Results: The prescription recovery rate was 99.9% with a relative standard deviation of 0.9%. Conclusion: Hydroquinone and propylparaben and oxybenzone have better resolution and the results are satisfactory