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AIM:To explore the relationship between metabolic risk factors and dry eye syndrome(DES).METHODS:Retrieved studies on the association of metabolic syndrome risk factors(hypertension,hyperglycemia,obesity,and hyperlipidemia) and DES were collected from PubMed,Web of Science,and the Cochrane Library in December 2015.Odds ratio(OR) with 95% confidence interval(Cl) were pooled to evaluate the final relationship.Subgroup analyses were conducted according to diagnostic criteria of DES.RESULTS:Nine cross-sectional studies and three case-control studies were included in this Meta-analysis.The pooled results showed that people with hypertension,hyperglycemia,and hyperlipidemia had a higher risk of suffering from DES(P<0.05),especially the typical DES symptoms.On the other hand,obesity did not increase the risk of DES.CONCLUSION:The present Meta-analysis suggests that all metabolic risk factors except obesity were risk factors for DES.
AIM: To explore the relationship between metabolic risk factors and dry eye syndrome (DES). METHODS: Retrieved studies on the association of metabolic syndrome risk factors (hypertension, hyperglycemia, obesity, and hyperlipidemia) and DES were collected from PubMed, Web of Science , and the Cochrane Library in December 2015. Odds ratio (OR) with 95% confidence interval (Cl) were pooled to evaluate the final relationship. Subgroup analyzes were conducted according to diagnostic criteria of DES.RESULTS: Nine cross-sectional studies and three case-control studies were included in this Meta-analysis. The pooled results showed that people with hypertension, hyperglycemia, and hyperlipidemia had a higher risk of suffering from DES (P <0.05), especially the typical DES symptoms. On the other hand, obesity did not increase the risk of DES.CONCLUSION: The present Meta-analysis suggests that all metabolic risk factors except obesity were risk factors for DES.