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目的探讨N-乙酰基转移酶(NAT2)基因多态性与肝癌易感性的关系。方法应用自动实时荧光Light-Cycler技术,分析78例肝癌患者和112例健康志愿者NAT24个位点的基因多态性,比较肝癌患者与对照组间频率差异。结果 肝癌吸烟组NAT2慢乙酰化基因型频率(37.5％)与对照吸烟组(17.9％)比较差异有显著性(X2=4.67,P<0.05),并使患肝癌的危险度提高了2.76倍;肝癌非吸烟组NAT2慢乙酰化基因型频率(26.3％)与对照非吸烟组(16.1％)比较差异无显著性(X2=1.47,P>0.05)。结论携带NAT2慢乙酰化基因型的吸烟者可能是肝癌的高危人群。
Objective To investigate the relationship between the polymorphism of N-acetyltransferase (NAT2) gene and the susceptibility to liver cancer. Methods The genotypes of NAT24 locus in 78 hepatocellular carcinoma patients and 112 healthy volunteers were analyzed using automatic real-time fluorescence Light-Cycler technique. The frequency differences between hepatocellular carcinoma patients and controls were compared. Results The frequency of NAT2 slow acetylation genotype (37.5%) in control group was significantly higher than that in control group (X2 = 4.67, P <0.05), and the risk of liver cancer increased by 2.76 times. The frequency of NAT2 slow acetylation genotype (26.3%) was not significantly different from that of control non-smoking group (16.1%) in non-smoking liver cancer group (X2 = 1.47, P> 0.05). Conclusions Smokers carrying the slow-acetylation NAT2 genotype may be at high risk for HCC.